Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.8K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

7.2K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
7.2K
Mutation, Gene Flow, and Genetic Drift01:09

Mutation, Gene Flow, and Genetic Drift

58.5K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
58.5K
Genetics of Speciation02:16

Genetics of Speciation

19.3K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
19.3K
Speciation Rates01:07

Speciation Rates

21.3K
Overview
21.3K
Genetic Variation01:25

Genetic Variation

321
Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...
321

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Low accuracy of complex admixture graph inference from f-statistics.

Genetics·2025
Same author

Phylogenomics of the tetraploid Hawaiian lobeliads: Implications for their origin, dispersal history, and adaptive radiation.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Leveraging graphical model techniques to study evolution on phylogenetic networks.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2025
Same author

Anomalous networks under the multispecies coalescent: theory and prevalence.

Journal of mathematical biology·2024
Same author

Ecophysiological adaptations shape distributions of closely related trees along a climatic moisture gradient.

Nature communications·2023
Same author

PhyloCoalSimulations: A Simulator for Network Multispecies Coalescent Models, Including a New Extension for the Inheritance of Gene Flow.

Systematic biology·2023

相关实验视频

Updated: Jul 16, 2025

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
10:08

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Published on: August 12, 2019

17.2K

内向的总结测试对评估跨血统的变化高度敏感.

Lauren E Frankel1, Cécile Ané1,2

  • 1Department of Botany, University of Wisconsin-Madison, Madison, WI 53706, USA.

Systematic biology
|September 12, 2023
PubMed
概括

进化速率变化在使用常见总结统计测试检测杂交时显著增加了假阳性. 这些方法可能需要在不同的遗传学研究中重新评估准确性.

科学领域:

  • 进化生物学是进化的生物学.
  • 基因组学就是基因组学.
  • 人类遗传学 是一个学科.

背景情况:

  • 杂交和内进越来越被认为是显著的进化力量.
  • 目前用于检测杂交的方法通常依赖于来自小分类群的总结统计数据.
  • 这些方法经常假设恒定的进化速率,这种条件在真实数据中往往没有得到满足.

研究的目的:

  • 量化进化速率变化对广泛使用的杂交检测试验的影响.
  • 为了评估D测试 (ABBA-BABA),D3测试和HyDe在变速下的稳定性.
  • 评估血统特异性和基因特异性速率变化如何影响这些测试的准确性.

主要方法:

  • 模拟的物种网络使用出生-死亡-杂交模型来表示现实的家族遗传场景.
  • 量化了跨物种谱系,基因和基因树边缘的速率变化的影响.
  • 评估了1型错误率 (错误发现网膜) 和检测杂交的功率.

主要成果:

  • 跨物种谱系的速率变化显著增加了所有测试方法的错误发现率.
  • D3测试对速率变化的敏感度很高,显示~80%的类型-1错误,这表明它检测速率偏差比网络化更多.
  • 增加的杂交事件降低了所有测试的功率,表明在复杂场景中隐藏信号的潜力.
关键词:
阿巴巴巴巴巴巴巴巴巴巴巴巴巴D-统计数据 统计数据D3 D3 D3 D3 D3 D3 D3 D3 D3 D3 D3 D3 D3 D3 D3 D3化物是什么 化物是什么添加剂图表 混合物的图表混合化混合化混合化人类基因组学学科.种类网络 种类网络 种类网络

更多相关视频

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
14:06

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER

Published on: June 23, 2012

15.3K
An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

22.9K

相关实验视频

Last Updated: Jul 16, 2025

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
10:08

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Published on: August 12, 2019

17.2K
Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
14:06

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER

Published on: June 23, 2012

15.3K
An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

22.9K

结论:

  • 广泛使用的杂交综合统计测试对进化速率变化敏感,导致膨胀的假阳性率.
  • D3测试特别容易受到速率变化的影响,可能误解时钟偏离为杂交.
  • 未来的研究应该考虑可靠的方法来计算速率变化或明确考虑它,以准确推断杂交事件.