献血者和被输血者之间的脑内出血
Jingcheng Zhao1, Klaus Rostgaard2,3, Elsa Lauwers4
1Department of Medicine, Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden.
JAMA
|September 12, 2023
概括
这项研究表明,输血与自发性脑内出血 (ICHs) 的风险之间存在潜在联系. 患有多个ICH的供体的输血与接受者的ICH风险增加有关,暗示可能存在传染性病因.
科学领域:
- 神经学
- 血液学
- 流行病学
背景情况:
- 大脑粉样血管病变 (CAA) 是自发性脑内出血 (ICH) 的常见原因.
- 之前的报道表明CAA可能通过受污染的阴道垂体激素注射传播.
- 与ICH相关的药物的输血传播潜力在很大程度上尚未被探索.
研究的目的:
- 调查献血者中自发性ICH是否与输血受体中自发性ICH的发展有关.
- 探讨可能导致自发性ICH的药物的输血传播.
主要方法:
- 一项探索性回顾性队列研究,利用来自瑞典和丹麦的全国性血液库和健康登记数据.
- 包括在1970/1980年至2017年期间接受红细胞输血的100多万名患者 (5-80岁).
- 根据捐赠者随后发生ICH (单一或多重) 或没有ICH的情况,分析了接受者的自发ICH风险.
主要成果:
- 接收来自捐赠者的输血后患上多种自发性内脏病的患者自身患上自发性内脏病的风险显著增加.
- 在瑞典 (调整后的危险比率[HR] 2.73) 和丹麦 (调整后的HR 2.32) 群体中都观察到这种关联.
- 对于从一次ICH发病的供体输血或对照结果的缺血性中风,没有发现显著的关联.
结论:
- 这些发现表明与多个自发性ICH相关的潜在输血传染剂.
- 在某些ICH病例中,这种关联可能对脑粉样血管病变 (CAA) 的输血传播起作用.
- 需要进一步的研究来证实这些发现,并研究潜在的选择偏差和混机制.
相关概念视频
01:15Blood Transfusion
603
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
603
02:45Blood Transfusion and Agglutination
10.9K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.9K
01:24Disorders of Hemostasis
987
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
987
01:22Bone Marrow Sampling and Transplants
356
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
356
01:19Rh Blood Group
1.5K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.5K