在老年人中,久坐不动行为和痴呆症的发生
David A Raichlen1,2, Daniel H Aslan1, M Katherine Sayre1
1Human and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles.
JAMA
|September 12, 2023
概括
老年人的久坐行为与痴呆的风险增加有关. 减少每天坐着的时间对大脑健康和预防认知衰退至关重要.
科学领域:
- 老年学
- 神经学
- 公共卫生
背景情况:
- 久坐不动行为是心脏代谢疾病和死亡的已知危险因素.
- 久坐不动与痴呆风险之间的关系尚不清楚.
- 了解这种关联对于开发认知衰退的预防策略至关重要.
研究的目的:
- 调查加速仪评估的久坐不动行为与老年痴呆症发病率之间的联系.
- 确定不同静坐行为指标 (时间,发作时间) 是否与痴呆风险相关.
主要方法:
- 使用了英国生物库的49841名年龄在60岁以上,在基线没有痴呆症的数据.
- 在一周内使用手腕加速度计评估静坐行为,分析时间,发作时间和发作次数.
- 在平均6.72年的随访期间使用了Cox的比例危险模型来分析与所有原因引起的痴呆症的关联.
主要成果:
- 在久坐和痴呆发病率之间发现了显著的非线性关联.
- 每天坐着15小时的人患痴呆的风险比率是每天9.27小时的3.21倍.
- 较长的平均和最大每日静坐时间也与痴呆症风险增加有关,但在调整了总静坐时间后,这种关联减少了.
结论:
- 较高的久坐行为与老年人全因痴呆的发病率显著增加有关.
- 这些发现凸显了减少每日久坐时间对认知健康的潜在重要性.
- 需要进一步的研究来确定久坐和痴呆风险之间的因果关系.
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