唐氏综合征妇女的怀孕,分娩和新生儿后果:一个匹配的队列研究,利用人口数据库
Abdullah Alnoman1,2, Haitham A Baghlaf3, Ahmad M Badeghiesh4,5
1Division of Maternal-Fetal Medicine, Obstetrics and Gynaecology, McGill University, Montreal, Canada. abdullah.alnoman@mail.mcgill.ca.
Archives of gynecology and obstetrics
|September 12, 2023
概括
唐氏综合征 (DS) 妇女的怀孕结果显示大多数分娩并发症的风险相似. 然而,患有DS的母亲面临着早产和新生儿不良后果的更高风险,包括胎儿死亡.
科学领域:
- 产科和妇科 产科和妇科
- 遗传学 遗传学 是一个
- 新生儿科学 新生儿科学
背景情况:
- 关于唐氏综合征 (DS) 妇女怀孕后果的数据有限.
- 人口数据库为研究怀孕中的罕见疾病提供了宝贵的资源.
研究的目的:
- 调查唐氏综合征 (DS) 妇女怀孕和分娩的结果.
- 为了比较具有和没有DS的妇女之间的孕产妇和新生儿结局.
主要方法:
- 医疗保健成本和利用项目的回顾性分析 - 全国住院患者样本数据库 (2004-2014).
- 使用ICD-9代码创建分娩队列,识别孕产妇的DS病例 (ICD-9代码758.0).
- 根据年龄,种族,收入和保险类型,在1:20的比例下,将患有DS的孕妇 (研究组) 与没有DS的妇女 (对照组) 相匹配.
主要成果:
- 分析包括184名患有DS的孕妇和3680名来自9,096,788次分娩的匹配对照.
- 大多数怀孕和分娩结果在各组之间是相似的,包括怀孕引起的高血压,妊娠期糖尿病和分娩方法.
- 患有DS的女性的早产风险显著增加 (aOR 3.09),孕期新生儿的风险较小 (aOR 2.70),子宫内胎儿死亡 (aOR 22.45),先天性异常 (aOR 7.92) 和胎儿染色体异常.
结论:
- 患有唐氏综合征 (DS) 的母亲所产生的新生儿面临着早产和不良后果的高风险.
- 建议增加产前监测,并为患有DS的患者提供关于这些风险的全面咨询.
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