双A通过血管化加速2型糖尿病患者的血管并发症 - 一种分子方法
N Mohanraj1, S Prasanth1, P Rajapriya2
1Department of Medical Research, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chennai, India.
International archives of occupational and environmental health
|September 12, 2023
概括
环境污染物双甲 (BPA) 与2型糖尿病 (T2DM) 的血管并发症有关. 这项研究发现,在T2DM患者中,较高的BPA水平与血管化标志物相关,这表明BPA在疾病进展中可能起作用.
科学领域:
- 内分泌学 在内分泌学.
- 环境健康 环境健康
- 心血管研究研究心血管研究
背景情况:
- 双甲 (BPA) 是一种环境污染物,与胰岛素抵抗和2型糖尿病 (T2DM) 有关.
- 血管并发症,包括血管化,是T2DM患者的重大问题,即使是那些控制葡萄糖水平的人.
- 在T2DM患者中,由于血管化而导致血管并发症的BPA水平存在有限的数据.
研究的目的:
- 测量T2DM患者和相关的血管并发症中的双甲 (BPA) 水平.
- 调查系统BPA水平与与这些患者血管化相关的基因表达之间的相关性.
主要方法:
- 这项研究涉及120名被诊断患有T2DM和相关血管并发症的参与者.
- 血清和尿液中的BPA水平使用ELISA量化.
- 在外周血液单核细胞 (PBMC) 中进行基因表达分析,使用定量实时PCR.
主要成果:
- 与对照组相比,在患有血管并发症 (包括心血管疾病和糖尿病病) 的T2DM患者中观察到血清和尿液BPA水平升高.
- BPA水平与血管化标志物有显著的正相关性:增加Runx2和IL-1beta基因表达,并减少Sirt1.
- 血清BPA也与TNF-alpha表达有显著的相关性,而尿液BPA没有.
结论:
- 双甲 (BPA) 含量与T2DM患者的血管化标志物和相关的血管并发症有关.
- 这项研究提供了新的证据,将BPA暴露与T2DM背景下的血管化联系起来.
- 这些发现强调BPA是T2DM血管并发症发展的潜在因素.
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