在气色谱质谱分析中,3,6-二二醇和p,p'-二二二三乙烯之间的相互干扰
Shanshan Zhou1, Qi Su2, Dan Zhong2
1College of Environment, Zhejiang University of Technology, Hangzhou, 310014, China. sszhou@zjut.edu.cn.
Environmental monitoring and assessment
|September 12, 2023
概括
环境污染物3,6-二碳醇 (36-CCZ) 和p,p'-二二三乙 (p,p'-DDT) 在分析过程中干扰. 必须改进分析方法以准确检测这些化合物,确保可靠的环境监测.
科学领域:
- 环境化学环境化学
- 分析化学 分析化学
- 质谱测量质量谱测量
背景情况:
- 多碳醇 (PHCZ),特别是3,6-二碳醇 (36-CCZ),是越来越多地检测到的环境污染物.
- 遗留的杀虫剂p,p '-二二三乙 (p,p '-DDT) 仍然在环境中无处不在.
- 由于干扰,对36-CCZ和p,p'-DDT的同时检测带来了分析挑战.
研究的目的:
- 为了研究3,6-二碳醇 (36-CCZ) 和p,p′-二二三乙烯 (p,p′-DDT) 之间的分析干扰.
- 为了确定气色谱-质谱 (GC-MS) 分析过程中干扰的原因.
- 提出解决环境样本中这些干扰化合物的方法.
主要方法:
- 气体染色学 (GC) 与单极或三极四极质谱学 (MS或MS/MS) 相结合.
- 对两种化合物的质谱和多重反应监测 (MRM) 过渡的分析.
- 使用SH-I-5MS毛细管柱对色谱分离的评估.
- 评估清洁列染色学和逆相高性能液体染色学 (HPLC) 用于样品预处理.
主要成果:
- 36-CCZ和p,p'-DDT都表现出一个m/z 235.5的基峰离子.
- 两种化合物都观察到相同的MRM过渡 (235 → 200和235 → 165).
- 在经过测试的GC条件下,SH-I-5MS列没有在36-CCZ和p,p'-DDT之间实现基线分辨率.
- 清洁列染色学和逆相HPLC成功分离了这两种化合物.
结论:
- 在36-CCZ和p,p'-DDT之间重叠的GC保留时间和相似的质谱可能导致环境研究中的量化不准确.
- 在仪器分析之前,有效的分离技术,如列色谱或HPLC至关重要.
- 实施强有力的质量控制措施对于减轻干扰和确保未来对这些污染物的环境监测数据准确性至关重要.
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