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蒙面贫血和血红素升高在糖转运抑制剂下:来自大型现实研究的发现
Yair Schwarz1,2, Pinchas Klein3,4,5, Liat Lev-Shalem5
1Division of Endocrinology, Diabetes and Metabolism, Sheba Medical Center, Derech Sheba 2, 5266202, Ramat Gan, Israel. Yair.Schwarz@Sheba.health.gov.il.
Acta diabetologica
|September 12, 2023
概括
糖载体抑制剂 (SGLT2i) 治疗增加了血红素水平,特别是在男性中,并减少了2型糖尿病患者的贫血患病率. 需要进一步的研究,以了解这些血位变化的临床意义.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 血液学 血液学 血液学
背景情况:
- 糖载体抑制剂 (SGLT2i) 与增加血红素的类效应有关.
- 由于SGLT2i诱导的血红素升高的临床意义,特别是在多细胞血症或掩盖性贫血的患者中,尚不清楚.
研究的目的:
- 调查SGLT2i治疗的2型糖尿病患者血红素升高的临床幅度和意义.
- 评估SGLT2i对心血管结果和贫血患病率的影响.
主要方法:
- 一项回顾性研究分析了9646名2型糖尿病成年患者的数据,这些患者接受了Dapagliflozin或Empagliflozin治疗.
- 在SGLT2i治疗前和治疗期间,血红素水平和相关变量进行了比较.
主要成果:
- SGLT2i治疗导致血红素水平显著增加 (2.1%),男性血红素水平升高.
- 在SGLT2i治疗下,贫血患病率从31.6%显著下降到20%.
- 影响血红素变化的因素包括性别,吸烟状态,SGLT2i类型,治疗前血红素,糖尿病持续时间,BMI和eGFR变化.
结论:
- SGLT2i治疗与显著的血红素升高,多细胞血症和减少贫血患病率有关.
- 需要进行进一步的研究,以确定多细胞血症的临床意义以及在SGLT2i治疗期间低正常血红蛋白水平的患者的适当治疗策略.
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