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在瘤学Patlak参数成像中使用KKinetics进行框架协议优化.

Qing Ye1, Hao Zeng1, Yizhang Zhao1

  • 1Shanghai United Imaging Healthcare Co., Ltd, Shanghai, China.

EJNMMI physics
|September 12, 2023
PubMed
概括

一个新的软件,ukinetics,为癌症研究提供精确的全身PET成像. 一个29的协议足以有效和可靠的瘤帕特拉克参数成像.

关键词:
帕特拉克 (Patlak) 是一个古老的城市.协议优化 协议优化整体体质的PET-PET.英国动力学

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科学领域:

  • 核医学是一种核医学.
  • 医学成像医学成像
  • 放射化学 放射化学是指辐射化学.

背景情况:

  • 全身PET成像提供了前所未有的灵敏度,使动态追踪器研究的高时间分辨率协议成为可能.
  • 优化时间框架对于在临床环境中平衡数据采集效率与计算需求至关重要.

研究的目的:

  • 在动态全身PET研究中对PMOD验证KKinetics软件包.
  • 优化用于使用18F-FDG的瘤帕特拉克参数成像的框架协议.

主要方法:

  • 在10名患者的60分钟18F-FDGPET扫描中,应用了6个时间框架协议 (100,61,48,29,19,12).
  • 基于Voxel的Patlak分析与自动衍生输入函数被用于生成参数图像.
  • 相关性和布兰德-阿尔特曼分析将不同的协议与100个参考框架进行比较.

主要成果:

  • 在帕特拉克的参数成像中,UKinetics与PMOD显示了轻微的差异.
  • 与100协议相比,具有≥29的协议显示了输入函数和动力参数的相对差异很小.
  • 在100和12协议之间观察到Ki损伤值的显著差异.

结论:

  • uKinetics提供相当于PMOD的瘤帕特拉克参数成像性能.
  • 对于瘤学中的18F-FDG Patlak应用,一个29的协议被认为是足够的和有效的.
  • 虽然19个产生了可接受的结果,但由于大量的定量差异,不建议使用12个.