北印度艾滋病毒-1类C感染者认知功能的性别差异
Anchal Sharma1, Manju Mohanty2, Teddy Salan3
1Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education & Research, Chandigarh, Punjab, India.
Journal of neurovirology
|September 12, 2023
概括
未经治疗的人类免疫缺陷病毒-1 (HIV-1) 类型C感染显著损害认知功能,并增加男性的抑郁症,在女性中观察到较小的影响. 早期治疗对于减轻这些影响至关重要.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 精神病学是一个精神病学.
背景情况:
- 人类免疫缺陷病毒-1 (HIV-1) C类是全球最常见的亚型,特别是在印度占主导地位.
- 与其他亚型 (如B类) 相比,HIV-1C类C类的认知障碍研究不足.
- 有限的研究存在于抗逆转录病毒疗法 (ART) 之前未经治疗的艾滋病毒-1 类 C 个体的认知效应.
研究的目的:
- 为了比较未经治疗的HIV-1clade C感染个体和北印度的健康对照之间的神经心理功能.
- 评估HIV-1 C类感染对认知领域和抑郁症的影响,考虑到性别差异.
- 为了研究HIV-1 clade C,认知功能和男性和女性抑郁症之间的关系.
主要方法:
- 对109名先前未接受ART的HIV-1 C类C参与者和110名人口统计学上匹配的健康对照进行了综合的神经心理电池.
- 评估了六个领域的认知表现,抑郁症和自我评估功能.
- 根据HIV-1状态和性别分析了群体差异,并控制了年龄和教育程度.
主要成果:
- 与男性对照者相比,HIV-1 clade C的男性参与者在所有领域都表现出明显更大的认知缺陷.
- 与女性对照对象相比,HIV-1 clade C的女性参与者仅表现出轻微的认知缺陷.
- 与女性相比,在HIV-1 clade C的男性中观察到显著抑郁症的患病率更高.
结论:
- 未经治疗的HIV-1 C类感染会对神经心理功能产生严重的负面影响,并增加抑郁症,特别是在男性中.
- 在HIV-1 C类感染的背景下,认知缺陷和抑郁水平在性别之间有显著差异.
- 迅速获得ART对于减少HIV-1C类别对认知健康和精神健康的衰弱影响至关重要.
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