脂乙醇与皮肤间酒精监测用于检测成年人饮酒的情况
Judith A Hahn1, Robin Fatch1, Nancy P Barnett2
1Department of Medicine, University of California, San Francisco.
JAMA network open
|September 12, 2023
概括
确定酸乙醇 (PEth) 的截止值为18.5 ng/mL有助于检测中年和老年人中大量饮酒的情况. 这种生物标志物切断可以改善在患者护理中对酒精使用的临床检测.
科学领域:
- 临床化学 临床化学
- 生物标志物 生物标志物
- 酒精使用检测检测
背景情况:
- 酒精生物标志物对于在临床环境中识别重度酒精消费至关重要.
- 缺乏对血中的关键生物标志物酸乙醇 (PEth) 的确定的切割值.
- 这项研究解决了中年和老年人中验证的PEth切断的需求.
研究的目的:
- 为了确定PEth的最佳切割值,以准确检测重度酒精消费.
- 评估PEth作为重度酒精使用的生物标志物在中年和老年人的队列中.
- 为了比较PEth的性能与经过验证的透皮酒精监测器 (SCRAM).
主要方法:
- 一项为期4周的诊断研究,涉及患有心房动症和当前酒精消费的成年人.
- 使用安全连续远程酒精监测器 (SCRAM) 进行透皮酒精测量.
- 使用基于SCRAM数据的曲线下面面积 (AUC) 分析的Youden J统计数据计算出最佳的PEth切线.
主要成果:
- 这项研究包括64名患者 (平均年龄65.5岁,84.4%是男性).
- 与SCRAM相比,最优的PETh切线为18.5 ng/mL,用于检测重度酒精消费的AUC为0.83.
- 这种切线实现了83.9%的灵敏度和72.7%的特异性.
结论:
- 脂乙醇 (PEth) 有效地识别了中年和老年人的重度酒精消费.
- 对于临床使用,建议PEth的切线值为18.5 ng/mL (或圆为20 ng/mL).
- 这种经过验证的切断值提高了在这个人口群体中重度饮酒的临床检测.
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