系统性免疫炎症指数对美国成年人高血压的值效应 (NHANES 2017-2020)
1Department of Cardiovascular Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang of Jiangxi, China.
Journal of hypertension
|September 12, 2023
概括
系统性免疫炎症指数 (SII) 与高血压风险有关,特别是在501.2.2的值以上. 较高的SII水平与成人高血压患病率的增加相关.
科学领域:
- 心血管健康 心血管健康
- 炎症生物标志物 炎症生物标志物
- 公共卫生 公共卫生
背景情况:
- 系统性免疫炎症指数 (SII) 与高血压之间的关联存在有限的研究.
- 高血压仍然是一个重大的全球健康问题,需要对新型预测标记物的研究.
研究的目的:
- 调查系统性免疫炎症指数 (SII) 与高血压患病率之间的潜在关系.
- 为了确定SII对高血压风险的潜在值效应.
主要方法:
- 从国家营养和健康数据库 (2017-2020年) 中对13,742名成年人的横截面分析.
- 系统性免疫炎症指数 (SII) 被用作暴露变量,高血压作为结果.
- 采用零碎后勤回归模型来分析非线性关联并确定切断点.
主要成果:
- 在SII和高血压之间观察到非线性关联.
- 确定了一个值效应,SII的切断点在501.2.2.
- 在这个值以上 (SII ≥501.2),高血压的患病率随着SII上升而显著增加 (OR,3.13;95% CI,2.04-4.81).
- 这种关联在各种子组中保持一致,包括性别,年龄,BMI,糖尿病和心血管疾病.
结论:
- 该研究确定了SII对高血压的值效应,在501.2.2的SII以上观察到的风险显著增加.
- SII可以作为一个有价值的炎症生物标志物来预测成人高血压风险.
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