维生素E补充剂 (单独或与其他抗氧化剂一起) 和中风:元分析
Enrico Maggio1, Valeria Proietti Bocchini1, Roberto Carnevale2,3
1Department of Clinical Internal, Anesthesiological, and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Nutrition reviews
|September 12, 2023
概括
仅仅补充维生素E并不能预防中风. 将维生素E与其他抗氧化剂结合使用可能会减少缺血性中风,但会增加出血性中风的风险,因此不适合用于预防中风.
科学领域:
- 营养科学 营养科学
- 心血管研究研究心血管研究
- 公共卫生 公共卫生
背景情况:
- 以前的研究表明,只有在没有其他抗氧化剂的情况下使用维生素E,才能有效预防心肌梗塞.
- 维生素E对中风发病率的影响,特别是与其他抗氧化剂结合,仍然不清楚.
研究的目的:
- 进行一项元分析,评估维生素E补充对中风发病率的影响.
- 为了比较单独的维生素E与与其他抗氧化剂相结合的维生素E的影响.
主要方法:
- 在PubMed,ISI科学网络,SCOPUS和Cochrane图书馆进行了系统的文献搜索.
- 包括16项随机对照试验 (RCT),涉及维生素E补充剂和中风发病率.
- 分析了维生素E剂量 (33-800 IU) 和随访期 (6 个月至 9.4 年) 的数据.
主要成果:
- 单独补充维生素E并没有显著降低缺血性或出血性中风的发生率.
- 结合维生素E和抗氧化剂补充剂可减少缺血性中风 (RR: 0.91; 95% CI: 0.84-0.99).
- 然而,联合补充剂显著增加了出血性中风风险 (RR: 1.22;95% CI: 1.0-1.48).
结论:
- 维生素E单一治疗与中风发病率的降低无关.
- 与维生素E和其他抗氧化剂的联合治疗显示出双重效应:减少缺血性中风,但增加出血性中风.
- 增加出血性中风的风险会抵消潜在的益处,导致推不使用维生素E来预防中风.
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