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Updated: Jul 16, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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研究非同名突变对甲状腺过氧化酶二聚体的影响

Mst Noorjahan Begum1,2,3, Rumana Mahtarin2,4, Sinthyia Ahmed5

  • 1Department of Genetic Engineering & Biotechnology, University of Dhaka, Dhaka, Bangladesh.

PloS one
|September 12, 2023
PubMed
概括

甲状腺过氧化酶 (TPO) 基因的遗传突变破坏了其二分体结构和功能,影响了甲状腺激素生物合成. 这项研究揭示了特定的TPO突变如何通过破坏蛋白质稳定和降低酶活性导致先天性甲状腺功能低下症.

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