智能手机技术在推进神经软标志研究工作中的潜在作用,重点是精神分裂症
Lucy E Gray1, Robert W Buchanan, Matcheri S Keshavan
1From Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (Ms. Gray, and Drs. Keshavan and Torous); Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD (Dr. Buchanan); Massachusetts Mental Health Center, Boston, MA (Drs. Keshavan and Torous).
Harvard review of psychiatry
|September 12, 2023
概括
神经软标志 (NSS) 显示出作为精神分裂症生物标志物的承诺,提供了临床症状和大脑功能之间的联系. 智能手机技术可以标准化NSS评估,改善研究和临床使用.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 生物标志物研究 生物标志物研究
背景情况:
- 自20世纪60年代以来,神经软征兆 (NSS) 在包括精神分裂症在内的各种精神疾病中得到了研究.
- NSS提供了临床表现和神经功能之间的直接联系,并且是具有成本效益的评估.
- 不一致的尺度,混变量和主观评级等挑战限制了NSS研究和临床应用.
研究的目的:
- 审查精神分裂症中神经软标志 (NSS) 的文献.
- 建议使用智能手机传感技术进行标准化和客观的NSS评估.
- 探索数字表型化在推动NSS研究和临床实施方面的潜力.
主要方法:
- 使用PubMed和APA PsycInfo进行了叙事文献搜索.
- 关键词包括:神经软体征,精神分裂症谱系障碍和精神病.
- 该研究建议利用智能手机传感技术和数字表型为NSS评估.
主要成果:
- 虽然神经学中存在相关的工作,但没有直接研究NSS与智能手机方法 (如数字表型) 相结合的NSS.
- 智能手机技术为可扩展,可访问和标准化的NSS测量提供了潜力.
- 这种方法可以区分特征与状态标记,并阐明NSS和神经障碍之间的关系.
结论:
- 神经软标志 (NSS) 作为精神分裂症的生物标志物具有显著的潜力.
- 整合智能手机传感技术和数字表型可以克服NSS评估当前的局限性.
- 这种创新方法可以提高诊断能力,并加深对精神疾病的理解.
相关概念视频
01:29Biological Causes of Schizophrenia
77
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
77
01:14Brain Imaging
257
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
257
01:17Schizophrenia
109
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
109
01:29Psychological and Sociocultural Causes of Schizophrenia
107
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
107