发生率和诱导因子与流西林相关的肝毒性在儿童中
Stefan Coombs1, Laure F Pittet2,3,4, Kailey Tang4
1Department of Pharmacy and General Medicine, The Royal Children's Hospital Melbourne, 50 Flemington Road Parkville, Victoria 3052, Australia.
富洛克萨西林可以在儿童中引起肝损伤,在本研究中发生率为17%. 年龄较大的儿童和服用多种药物的儿童面临更高的风险,流西林诱导的肝毒性.
科学领域:
- 儿科药理学 儿科药理学
- 肝病学 肝病学是一种肝病学.
- 药物不良反应 药物不良反应
背景情况:
- 流西林诱导的肝毒性在成年人中被认可,但在儿童中研究较少.
- 这种抗生素经常被处方给儿科患者.
- 由于儿科数据有限,因此需要对富洛克萨西林在儿童的肝脏效应进行研究.
研究的目的:
- 为了确定在接受静脉注射治疗的儿科患者中引起的肝毒性的发生率.
- 为了确定与儿童的克洛西林诱导的肝损伤相关的风险因素.
- 评估这种不良药物反应的严重程度和时间进程.
主要方法:
- 在两年时间内,对儿童 (0-18岁) 进行了回顾性审计,这些儿童接受了24小时以上的静脉注射黄西林.
- 在服用抗生素之前和之后,分析了肝功能测试.
- 使用已知方法评估因果关系,如罗塞尔·乌克拉夫因果关系评估方法和纳拉诺标准.
主要成果:
- 富洛克萨林诱导的肝毒性发生率为17% (66/393名儿童).
- 高龄 (尤其是12-18岁) 和同时使用多种肝毒药物是显著的危险因素.
- 严重的肝损伤发生在14-20%的受影响儿童中,平均发病时间为4天,在5天内消失.
结论:
- 年龄较大的儿童和服用多种肝毒药物的儿童有较高的风险,因流西林引起的肝损伤.
- 这些发现凸显了在接受克洛西林的儿科患者中监测肝功能的重要性.
- 进一步的研究可能会为儿童的这种常见抗生素提供更安全的处方做法.
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