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缺氧缺血脑病与甲状腺激素之间的关联
Asli Okbay Gunes1, Aydin Bozkaya1
1Neonatal Intensive Care Unit, Sanliurfa Training and Research Hospital, Sanliurfa, Turkey.
Therapeutic hypothermia and temperature management
|September 12, 2023
概括
甲状腺刺激激素 (TSH) 和自由甲状腺素 (fT4) 水平在治疗性低温症 (TH) 的新生儿中不同. 在HIE/TH婴儿的第五天解释这些甲状腺功能测试时,建议谨慎.
科学领域:
- 新生儿医学 新生儿医学
- 内分泌学 在内分泌学.
- 儿科神经学 儿科神经学
背景情况:
- 缺氧缺血性脑病变 (HIE) 是一个严重的出生并发症.
- 治疗性低温 (TH) 是新生儿HIE的标准治疗方法.
- 甲状腺功能可能会受到HIE和TH的影响,但数据有限.
研究的目的:
- 为了比较新生儿的血清TSH和ft4水平,与经历TH的不同HIE阶段.
- 为了评估新生儿的TSH和FT4水平,与HIE/TH与对照组对比.
主要方法:
- 追溯研究 (2020年1月至2022年12月).
- 与患有HIE/TH的新生儿 (第2期和第3期) 与患有新生儿暂时性呼吸暂停 (TTN) 的新生儿进行了比较.
- 在出生后第五天测量了血清TSH和ft4.
主要成果:
- 第三阶段的HIE/TH新生儿的TSH和ft4水平低于第二阶段的HIE/TH.
- 与TTN对照组相比,HIE/TH新生儿的TSH水平较高,但FT4类似.
- 在HIE/TH (特别是第二阶段) 中,TSH升高率较高,而不是TTN.
- 在第三阶段,较高低FT4率HIE/TH与TTN相比.
结论:
- 在接受TH治疗的新生儿中,TSH和FT4水平因HIE阶段而异.
- 在HIE/TH新生儿中解释第5天的甲状腺功能测试需要谨慎,因为TSH的潜在升高和FT4的降低.
- 这些发现可以防止在HIE/TH婴儿中不必要重复测试.
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