开启三氧化调查的新时代:ATOdbb
Yanan Jiang1, Jianing Li2, Yujie Liu2
1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150081, China; Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin 150081, China.
Computers in biology and medicine
|September 12, 2023
概括
三氧化物 (ATO) 数据库 (ATOdb) 汇编了关于ATO的广泛数据.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 生物信息学和计算生物学
- 在瘤学瘤学.
背景情况:
- 三氧化物 (ATO) 是急性肌细胞性白血病 (APL) 和其他癌症的关键治疗方法.
- 了解ATO的机制和确定协同作用的药物组合对于推进癌症治疗至关重要.
研究的目的:
- 为三氧化 (ATO) 开发一个全面的综合数据库 (ATOdb).
- 促进对ATO机制的深入分析,并发现新的治疗策略.
主要方法:
- 从3479篇研究文章中手动编译与ATO相关的数据.
- 整合有关ATO目标,条件和药物组合的数据.
- 开发数据可视化和分析工具 (例如PPI,miRNA-mRNA相互作用).
主要成果:
- 在2300个ATO目标,80个疾病和262种药物组合中,ATOdb包含8373个关联.
- 包括有关治疗效果,副作用和分子相互作用的详细信息.
- 包括用于药物相似性,PPI和miRNA-mRNA关系的数据可视化和分析工具.
结论:
- ATOdb是研究ATO机制和识别新药组合的宝贵资源.
- 该数据库支持合理使用药物和个性化癌症治疗.
- 全球研究人员可以免费在线访问ATOdb.
相关概念视频
Anticholinesterase Agents: Poisoning and Treatment
918
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
918
Atomic Absorption Spectroscopy: Lab
478
For AAS measurements, samples must be introduced as clear solutions, often requiring extensive preliminary treatment to dissolve materials like soils, animal tissues, and minerals. Common methods for sample preparation include treatment with hot mineral acids, wet ashing, combustion in closed containers, high-temperature ashing, or fusion with reagents.
Solutions containing organic solvents, such as low-molecular-mass alcohols, esters, or ketones, enhance absorbances by increasing...
Solutions containing organic solvents, such as low-molecular-mass alcohols, esters, or ketones, enhance absorbances by increasing...
478
Atomic Emission Spectroscopy: Interference
223
In atomic emission spectroscopy (AES), high-temperature atomizers excite a broad range of elements and molecules that generate complex emissions from sources such as oxides, hydroxides, and flame combustion products in the flame or plasma. Several strategies can be employed to minimize spectral interferences caused by overlapping emission lines or bands. These include increasing instrument resolution, choosing alternative emission lines, optimally placing the detector in low-background regions,...
223


