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用 pembrolizumab治疗的固体瘤患者的瘤动态超出了疾病进展的范围

Brian G Topp¹, Madhav Channavazzala², Kapil Mayawala¹

¹Merck & Co., Inc, Rahway, NJ, USA.

|September 12, 2023

概括

在癌症进展之后的 pembrolizumab 治疗为许多癌症患者提供了临床益处. 一个显著的子组经历了瘤缩或稳定的疾病,在黑色素瘤,肺癌,胃癌,头癌,脏癌和泌尿器癌中表现出有意义的疗效.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
临床试验分析

背景情况:

许多癌症患者在最初的疾病进展之后继续治疗.
这种治疗策略的临床益处和持续时间尚未完全理解.
布罗利祖马布是一种免疫疗法剂,用于各种晚期癌症.

研究的目的:

量化治疗布罗利祖马布超过疾病进展 (PD) 的患者的临床益处和持续时间.
分析多种癌症的治疗结果,包括黑色素瘤,NSCLC,GC,HNSCC,ccRCC和UC.

主要方法:

对799名接受布罗利祖马布治疗超过RECIST v1.1 PD.的患者进行了回顾性分析.
瘤反应的评估,包括病变直径的减少和稳定的疾病,在后进展期.
结果按癌症类型分层分类.

主要成果:

一部分患者 (在癌症类型中从8.9%到24.4%) 显示病变直径在进展后减少了≥30%.
大多数患者 (64.8%至75.9%) 呈现出稳定的目标病变动态.
布罗利祖马布在经过RECIST v1.1进展后治疗的小组患者中显示出有意义的疗效.

结论:

布罗利祖马布为一组患有晚期癌症的患者提供了临床益处,这些患者在疾病进展后接受治疗.
经过 pembrolizumab 的治疗,瘤的进展可能会导致瘤缩或稳定.
这些发现支持在患有PD的选定患者中继续使用 pembrolizumab.

关键词:

清晰细胞脏细胞癌.胃癌胃癌是一种胃癌.头部和部状细胞癌瘤黑色素瘤是一种黑色素瘤.非小细胞肺癌的肺癌.这就是Pembrolizumab.进展后的反应反应.尿路细胞癌是什么意思

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