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Updated: Jul 16, 2025

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在体外应用中,作为避免代谢降解的策略,VHL-修改的PROTEOLYSIS T准金马 (PROTACs)

Beatrice Castellani1, Michela Eleuteri2, Stefano Di Bona1

  • 1Molecular Horizon s.r.l., Bettona 06084, Italy.

Journal of medicinal chemistry
|September 12, 2023
PubMed
概括

蛋白质溶解向金马 (PROTACs) 是一种治疗蛋白质降解的治疗策略. 研究人员从VHL-连接体裂变中确定了一种特定的代谢物,确定了prolyl内酶作为关键酶,并开发了更稳定的PROTAC类似物.

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