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Updated: Jul 16, 2025

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C. difficile 毒害神经元和细胞周细胞,导致神经元炎症

John Manion1,2,3, Melissa A Musser4, Gavin A Kuziel3,5

  • 1Department of Urology, Boston Children's Hospital, Boston, MA, USA.

Nature
|September 12, 2023
PubMed
概括

通过针对神经元和细胞周的毒素B (TcdB) 引起炎症. 阻断神经性炎症通路, 如P物质和CGRP, 为CDI提供了一个有前途的治疗策略.

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Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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