在患有多发性硬化症的患者中,认知障碍和神经成像之间的关联
Olivia Wilcox1, Moein Amin2, Laura Hancock1
1Neurological Institute, Section of Neuropsychology, Cleveland Clinic, Cleveland, OH USA.
概括
甲状腺缩与多发性硬化症 (MS) 患者的认知能力下降有关. 减少的胸膜体积与MS患者在记忆和处理速度测试中的表现较差相关.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 临床神经学 临床神经学
背景情况:
- 多发性硬化症 (MS) 的特点是炎症和神经退行,往往导致认知功能障碍.
- 在MS患者中观察到大脑缩,特别是在丘脑,但其与认知障碍的直接联系尚未完全理解.
- 丘陵体作为中央中继器的作用影响着各种认知功能,这表明其缩可能导致认知缺陷.
研究的目的:
- 研究患有多发性硬化 (pwMS) 患者的乳头缩和认知障碍之间的关联.
- 为了确定下降的乳头体积是否预测pwMS的特定认知缺陷.
主要方法:
- 追溯分析121 pwMS与匹配的神经心理测试和MRI数据.
- 分组LASSO线性回归利用乳头体积作为预测因素,控制人口统计和MRI共变量.
主要成果:
- 在所有测试中,认知障碍率从19%到44%不等.
- 在符号数字模式测试,简要视觉空间记忆测试 (延迟),加利福尼亚口语学习测试 (延迟和总) 和步道制作测试A部分中,在下面的乳头体积和受损的表现之间发现了显著的关联.
结论:
- 胸膜体积独立地与pwMS中的处理速度和记忆缺陷有关.
- 这些发现凸显了lamus作为MS相关认知功能障碍的关键结构.
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