关于怀孕期间肥胖如何影响结果的研究 (SHAPES):前性队列研究的协议
Nicola Heslehurst1, Raya Vinogradov2,3, Giang T Nguyen2
1Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK nicola.heslehurst@newcastle.ac.uk.
BMJ open
|September 12, 2023
概括
孕产妇的肥胖可能会导致妊娠并发症. 这项研究将体重指数 (BMI) 与其他肥胖度量进行比较,以更好地预测孕妇的不良结果. 这些发现旨在改善风险评估,以改善母婴护理.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 公共卫生 公共卫生
背景情况:
- 孕产妇的肥胖是妊娠并发症的重要危险因素,如妊娠糖尿病和子宫前.
- 目前英国的指导方针依赖身体质量指数 (BMI) 来识别危险妊娠,但BMI可能不准确地反映脂肪分布.
- 肥胖度的测量,如腰围和内脏脂肪,可以更准确地预测怀孕并发症.
研究的目的:
- 评估各种肥胖度指标在预测不良妊娠结果方面的预后性能.
- 为了比较肥胖度测量的预测准确性与潜在队列中的传统BMI.
- 开发和验证多变量模型,以改善妊娠并发症风险分层.
主要方法:
- 前性队列研究 (SHAPES) 招募了1400名第一季度的孕妇.
- 收集早期怀孕脂肪测量,临床和社会人口统计数据.
- 使用回归方法对脂肪度和BMI进行比较,并进行模型开发和验证.
主要成果:
- 这项研究旨在确定脂肪度测量或组合模型是否能比BMI更好地预测妊娠并发症.
- 分析将包括校准,区分和预测模型的内部验证.
- 结果将为孕妇风险评估策略的潜在更新提供信息.
结论:
- 肥胖度的测量可以比单独的BMI更准确地预测妊娠并发症.
- 改进的风险预测可以导致危险怀孕的及时和有针对性的干预.
- 这项研究可以通过完善当前的临床指导方针来提高母亲和婴儿的结果.
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