[用于生物转化类固醇关键中间体和智能工业生产的菌株的构建]
Jinhui Feng1,2, Rujin Zhang3, Zhengbin Zhang3
1Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Sheng wu gong cheng xue bao = Chinese journal of biotechnology
|September 12, 2023
概括
植物醇现在通过微生物转化生产类固醇制药中间体. 新的菌株和智能工艺提高了工业生产效率和可持续性,以实现更绿色的制药制造.
科学领域:
- 生物技术和工业微生物学
- 制药合成 制药合成
- 合成生物学 合成生物学
背景情况:
- 类固醇激素制药是一种主要的药物类别,植物醇取代了植物衍生的原蛋白作为主要的原料.
- 植物醇是大豆油生产的副产品,为合成关键类固醇中间体,如androstenedione (AD) 提供了丰富且具有成本效益的来源.
- 生产这些中间体的传统微生物方法面临着长代谢途径,副产品和复杂调节的挑战,阻碍了工业的可扩展性.
结论:
- 开发了新的菌株和智能工艺,用于从植物中生产工业规模的类固醇制药中间体,克服了传统方法的局限性.
- 这些进步有望使类固醇药物的制造更有效率,更绿色,经济更有价值.
- 合成生物学有可能在中间开发和活性药物成分的直接生物合成方面进一步创新.
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