基于蛋白质的纳米载体和纳米治疗药物用于感染和炎症
Nupur Nagar1, Goutami Naidu1, Amit Mishra1
1Department of Biosciences and Bioengineering (N.N., G.N., K.M.P.) and Centre for Nanotechnology (K.M.P.), Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India; and Cellular and Molecular Neurobiology Unit, Indian Institute of Technology Jodhpur, Jodhpur, Rajasthan, India (A.M.).
The Journal of pharmacology and experimental therapeutics
|September 12, 2023
概括
蛋白质纳米平台为传染性和炎症性疾病提供先进的药物输送. 这篇评论强调了它们的潜力,重点关注人类和致病蛋白质,用于治疗癌症和病毒感染等疾病.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 传染病和炎症性疾病是全球主要的死亡原因,COVID-19等大流行病加剧了这种情况.
- 蛋白质作为药物,药物标和生物标志物至关重要.
- 纳米技术通过持续释放和纳米维度的优势来增强药物输送.
研究的目的:
- 审查基于蛋白质的纳米平台用于传染性和炎症性疾病.
- 在纳米医学中强调人类和致病源的蛋白质.
- 讨论优势,ADME参数和临床翻译挑战.
主要方法:
- 基于蛋白质的纳米载体和纳米治疗药物的综合文献综述.
- 专注于癌症和病毒性疾病的应用.
- 分析来自不同生物体的蛋白质,特别是人类和病原源.
主要成果:
- 蛋白质纳米平台将蛋白质优势与纳米配方的好处相结合.
- 蛋白质在纳米形式中充当载体,治疗,诊断和治疗术的功能.
- 对主要传染病和炎症性疾病的基于蛋白质的纳米平台进行广泛的探索.
结论:
- 基于蛋白质的纳米药物在治疗感染和炎症方面显示出显著的前景.
- 了解药理学优势和ADME参数是关键.
- 解决当前的瓶对于成功的临床翻译至关重要.
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