3-4小时的卵细胞检索-ICSI间隔优化了40岁以上女性的临床结果
Jingbo Chen1,2, Yanfang Wang1,3,4, Cong Fang5,6,7
1Reproductive Medicine Research Center, Sixth Affiliated Hospital of Sun Yat-Sen University, NO.17, Shougouling Rd, Guangzhou, 510275, China.
Scientific reports
|September 12, 2023
概括
对于40岁以上接受细胞内精子注射 (ICSI) 的女性来说,卵细胞检索和ICSI之间的时间显著影响了结果. 3-4小时的最佳间隔最大限度地提高了受精率和临床怀孕率.
科学领域:
- 生殖医学 生殖医学
- 胚胎学 胚胎学
- 在体外受精过程中受精.
背景情况:
- 高龄的母亲 (40岁以上) 在辅助生殖技术方面面临着独特的挑战.
- 在细胞内注射精子 (ICSI) 周期中优化程序的时间对于成功至关重要.
研究的目的:
- 为了确定40岁以上女性的卵细胞提取和ICSI之间的理想时间间隔.
- 确定这个间隔对胚胎学和临床结果的影响.
主要方法:
- 在40岁以上的女性中,对1476次ICSI新鲜周期的回顾性分析.
- 使用多变量线性和逻辑回归进行统计分析,以评估卵细胞采集 (OPU) - ICSI间隔的影响.
主要成果:
- OPU-ICSI间隔与受精率和临床怀孕率有显著的相关性.
- 超过4小时的间隔降低了临床妊娠率,尽管受精率可能更高.
结论:
- 在接受ICSI的40岁以上女性中,3-4小时的OPU-ICSI间隔是实现优异胚胎和临床结果的最佳选择.
- 仔细考虑OPU-ICSI时机对于最大限度地提高这一患者群体的成功至关重要.
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