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在婴儿配方中添加后生物质的安全性和有效性:系统性审查和元分析
Xifeng Liang1,2, Yu Li1,2, Zhijiao Zhao1
1School of Nursing, Weifang Medical University, Weifang, China.
Pediatric research
|September 12, 2023
概括
婴儿配方中的后生菌是安全的,不增加不良事件. 然而,它们并没有显著改善婴儿生长或消化症状,尽管便分泌IgA (SIgA) 略有增加.
科学领域:
- 营养科学 营养科学
- 儿科 儿科 儿科
- 微生物学 微生物学
背景情况:
- 后生物质越来越多地被添加到婴儿配方奶粉中,但它们的安全性和有效性需要彻底调查.
- 现有的研究缺乏对后生菌对婴儿健康结果的影响的全面分析.
研究的目的:
- 进行系统性审查和元分析,评估婴儿配方奶粉中后生物质的安全性和有效性.
- 为了比较婴儿配方奶粉与没有后生菌剂的严重不良事件 (SAE),消化症状和生长参数.
主要方法:
- 搜索了主要的数据库 (PubMed,Embase,Web of Science,ProQuest) 进行随机对照试验 (RCT) 到2023年2月.
- 包括9个RCT,涉及2065名参与者.
- 分析了SAE,消化症状,便分泌免疫球蛋白A (SIgA) 度和生长指数的数据.
主要成果:
- 婴儿配方中的后生物补充剂并没有显著增加SAE的发生率或常见的消化问题,如结肠,膨胀,腹或吐.
- 没有观察到对每日体重增加,身体长度增加或头周长增加的显著影响.
- 便SIgA度的统计学上显著增加被注意到,尽管证据的确定性非常低.
结论:
- 在婴儿配方中添加后生菌对婴儿是安全的,不会增加不良事件或胃肠道疾病的风险.
- 目前的证据表明,后生物质并不能显著增强婴儿生长或缓解常见的消化系统症状.
- 虽然后生菌可能会增加便SIgA,但它们在婴儿配方奶粉中的整体疗效仍然有限,因此需要进一步研究.
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