白血病阶段粘膜相关的淋巴组织淋巴瘤
Takayuki Yotsuyanagi1, Naoto Tomita2, Yusuke Saiki1
1Hematology and Oncology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, Kawasaki, Kanagawa, 216-8511, Japan.
International journal of hematology
|September 12, 2023
概括
本病例报告详细介绍了一例罕见的白血病阶段粘膜关联淋巴组织淋巴瘤 (MALT) 在一个78岁的男人. 诊断包括流细胞计,成像和分子分析,证实广泛的MALT淋巴瘤.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 白血病阶段粘膜关联淋巴组织 (MALT) 淋巴瘤是一种非常罕见的血液性恶性瘤.
- 马尔特淋巴瘤通常发生在节外部位,而它们在白血病阶段的呈现并不常见.
研究的目的:
- 报告一种罕见的白血病阶段MALT淋巴瘤病例.
- 要突出诊断挑战和多学科的方法需要这种罕见的条件.
主要方法:
- 周围血流细胞测量以确定异常的B细胞.
- 阳位子辐射断层扫描/计算机断层扫描 (PET/CT) 用于分期和识别受影响的部位.
- 组织活检上的免疫组织化学和光 in situ 杂交 (FISH).
- 聚合酶链反应 (PCR) 用于免疫球蛋白重链 (IgH) 基因重排分析.
主要成果:
- 流细胞测量显示B细胞淋巴瘤具有中大异常细胞.
- PET/CT显示了轨道,骨髓和脏的异常吸收.
- 组织病理学和分子分析证实了MALT淋巴瘤.
- 在轨道和骨髓样本中相同的IgH基因重组表明单克隆起源.
结论:
- 患者被诊断出患有白血病阶段的MALT淋巴瘤,涉及骨髓,外周血液,右轨道和脏.
- 这一案例强调了为罕见的淋巴细胞恶性瘤进行全面诊断工作的重要性.
- 早期和准确的诊断对于适当管理MALT淋巴瘤至关重要.
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