混合重金属对阻塞性肺功能的影响:从流行病学和毒基因组学数据的发现
1Department of Pharmacy, College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Sunchon, Jeonnam, 57922, Republic of Korea. duchainguyen1706@gmail.com.
Environmental geochemistry and health
|September 12, 2023
概括
像,和这样的重金属与阻塞性肺功能 (OLF) 有关. 在两性中,与肺功能减弱 (FEV1/FVC比率) 的关联最强,涉及炎症和氧化应激途径.
科学领域:
- 环境健康 环境健康
- 肺部医学 肺部医学
- 毒理学 毒理学 毒理学
背景情况:
- 阻塞性肺功能 (OLF) 是一个重要的健康问题,不完全理解环境风险因素.
- 混合重金属暴露 (,,) 与不同人群中的OLF的特定分子关联在很大程度上是未知的.
研究的目的:
- 为了研究混合重金属 (,,) 和阻塞性肺功能 (OLF) 的血清水平之间的关系,通过一秒内强制呼气体积 (FEV1) /强制生命能力 (FVC) 的比率来衡量.
- 鉴定分子机制和关键基因,转录因子和因重金属暴露而参与OLF发展的miRNA.
主要方法:
- 在大量男性和女性队列 (n=6221) 中分析血清重金属含量和螺旋计数据 (FEV1/FVC比率).
- 在分析中识别与OLF和重金属暴露相关的基因,转录因子 (例如NFKB2) 和微RNA (例如hsa-miR-155-5p,hsa-miR-203a-3p).
- 评估生物途径,包括炎症,氧化应激和纤维化.
主要成果:
- 血清水平与FEV1/FVC比率在两性和整体人口中相反相关.
- 观察到与,与之间关于FEV1/FVC比率的显著相互作用.
- 七个基因 (CYP1A1,CRP,CXCL8,HMOX1,IL6,NOS2,TNF) 被确定为重金属在OLF病变发生过程中的潜在目标,主要是通过共同表达网络.
结论:
- 在研究的重金属中,被确定为对OLF病变产生最重要的贡献者.
- 炎症和氧化应激途径,以及肺纤维化,是重金属诱导的OLF中关键的生物学过程.
- 需要进一步的研究来验证这些发现,并阐明长期重金属暴露对不同年龄组的OLF的影响.
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