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细菌脂多糖诱导的内皮激活和功能障碍:败血症的新预测和治疗范式

Min Wang1,2, Jun Feng1,2, Daixing Zhou3,4

  • 1Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 JieFang Avenue, Wuhan, 430030, Hubei, People's Republic of China.

European journal of medical research
|September 12, 2023
PubMed
概括

来自グラム阴性细菌的脂聚糖 (LPS) 通过激活内皮细胞,引发严重的败血症,导致炎症和损伤. 保持内皮功能是减少败血症发病率和死亡率的关键.

关键词:
内皮细胞是内皮细胞.脂聚糖类糖化物 (Lipopolysaccharide) 是一种脂肪聚糖.败血症 这是一种败血症.在 TLR4 中,

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Lipopolysaccharides (LPS) are crucial components of the outer membrane of Gram-negative bacteria, serving both structural and functional roles. It contributes to membrane stability and protects bacteria from host immune responses. LPS is composed of three major regions—lipid A, a core oligosaccharide, and an O antigen. The biosynthesis and assembly of LPS involve a highly coordinated set of enzymatic reactions and transport mechanisms. Additionally, LPS is recognized as an endotoxin,...
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