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Updated: Jul 16, 2025

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Published on: January 5, 2017

外囊结节延伸和头部和部瘤沉积物状细胞癌

Leyre González-Vallejo¹, Javier Blanco-Sainzdelamaza², Arrate Querejeta-Ayerra¹

¹Radiotherapy Department, Donostia University Hospital, San Sebastian, Spain.

Cancer reports (Hoboken, N.J.)

|September 13, 2023

概括

头部和部状细胞癌 (HNSCC) 的瘤沉积 (TDs) 表明预后比外延伸 (ENE) 更差. 即使在积极的治疗中,TDs也与明显较低的整体存活率 (OS) 相关,这表明需要进行单独的TNM分期.

科学领域:

在瘤学瘤学.
手术病理学手术病理学
癌症的分期癌症的分期

背景情况:

瘤沉积 (TDs) 是头部和部状细胞癌 (HNSCC) 的一个未被认可的特征.
目前,在AJCC第八版的TNM分期中,TD被归类为HNSCC的外节延伸 (ENE).
与ENE相比,TDs的独特预后价值仍然不清楚.

研究的目的:

为了评估瘤沉积 (TDs) 在头部和部状细胞癌 (HNSCC) 的预后意义.
为了比较TDs患者的结局与异节延伸 (ENE) 患者的结局.
评估TDs对HNSCC患者整体生存期 (OS) 和进展时间的影响.

主要方法:

观察性,回顾性,非随机化研究设计.
包括接受初始手术切除,部剖析和辅助治疗的HNSCC患者.
统计分析比较了TD和ENE患者的进展时间和整体存活率 (OS).

主要成果:

总共有71名HNSCC患者被分析;50人患有ENE,21人患有TD (有或没有ENE).
在ENE和TDs组之间,进展的中位时间显著不同 (p=.002).
三年后的生存率为TD的38.4%,而ENE的60.4% (p=.021),与ENE相比,TD的危险比率为4.341 (p=.044).

结论:

在HNSCC中,瘤沉积 (TDs) 与外节延伸 (ENE) 相比,具有显著较低的整体存活率 (OS).
这些发现支持TD的预后较差,即使在强化辅助治疗后.
TDs值得考虑在HNSCC TNM分期内进行单独分类,以更好地反映预后.

关键词:

额外节点延伸额外节点延伸头部和部状细胞癌瘤 pN3b分类的分类方式预后预后预后瘤沉积物是一种瘤沉积物.

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