代谢功能障碍相关的脂肪性肝病 (MASLD):一篇最先进的综述
Wah-Kheong Chan1, Kee-Huat Chuah1, Ruveena Bhavani Rajaram1
1Gastroenterology and Hepatology Unit, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Journal of obesity & metabolic syndrome
|September 13, 2023
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的公共卫生问题. 早期识别和管理,重点关注生活方式和心血管健康,对于更好的患者结果至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
- 公共卫生 公共卫生
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 是与代谢综合征相关的脂肪性肝病的新术语.
- 它是慢性肝病的最常见原因,也是肝脏相关疾病和死亡的主要驱动因素.
- 解决像MASLD这样的肥胖和相关疾病需要所有利益相关者的集体努力.
研究的目的:
- 强调需要对MASLD患者进行明确的评估和转诊途径.
- 突出管理MASLD患者心血管疾病风险的重要性.
- 讨论目前和新兴的治疗策略和MASLD患者分层方法.
主要方法:
- 使用非侵入性测试进行患者评估和分层.
- 实施生活方式干预作为主要的管理策略.
- 考虑新的抗高血糖药物,并根据疾病进展调整现有的药物.
主要成果:
- 非侵入性测试有助于识别严重的MASLD,以便转诊专家,而较不严重的病例则在初级保健中进行管理.
- 心血管疾病风险管理至关重要,因为它是导致死亡的主要原因.
- 补偿性晚期慢性肝病和临床显著的门内高血压概念有助于风险分层.
结论:
- 使用非侵入性方法的简化评估和转诊系统对于有效的MASLD管理至关重要.
- 综合管理MASLD应包括生活方式的改变,心血管风险的降低,并考虑.
- 虽然没有批准的特定药物,但新兴疗法和仔细的药物调整是管理MASLD进展的关键.
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