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自然产品通过影响基因组甲基化/脱甲基化来调节表观遗传机制:向癌细胞
Dawid Dorna1, Adriana Grabowska2, Jarosław Paluszczak1
1Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, Poznań, Poland.
British journal of pharmacology
|September 13, 2023
概括
自然产品可以通过改变基因组甲基化来影响癌症,这是表观遗传学研究中经常被忽视的过程. 本综述探讨了像黄类和类等化合物如何影响基因素甲基化酶,影响癌症进展.
科学领域:
- 表观遗传学和天然产品化学
- 癌症生物学和化疗预防
背景情况:
- 表观遗传修饰,包括DNA甲基化和基因素乙化,是已知的癌症标.
- 激素甲基化,特别是其编写和除器在致癌过程中的作用越来越明显,但却越来越少被探索.
- 自然产品为调节表观遗传机制提供了多样化的化学支架.
研究的目的:
- 审查天然产品对基因素甲基化/脱甲基化酶的影响.
- 突出这些相互作用在致癌和癌症进展中的重要性.
- 强调天然化合物的潜力作为癌症治疗中的表观遗传调节剂.
主要方法:
- 对研究天然产品和基因素甲基化酶的文献综述.
- 分析了影响基因组甲基转移酶 (例如EZH2) 和脱甲基酶 (例如LSD1) 的植物化学物质数据.
- 检查证据,将这些相互作用与癌症相关的基因表达和细胞功能联系起来.
主要成果:
- 许多天然化合物 (多,黄,,等等). 调节关键的素甲基化酶.
- 植物化学物质会影响诸如EZH2和LSD1.1之类的酶的表达和活性.
- 通过天然产品调节组织素甲基化,影响癌细胞的增殖,迁移和亡.
结论:
- 天然产品代表了在癌症预防和治疗中向激素甲基化的有希望的途径.
- 对研究较少的组胺基转移酶和脱甲基酶进行进一步的研究是有必要的.
- 了解这些表观遗传相互作用可以导致新的化疗预防和治疗策略.
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