十米3在thalamostriatal投射的形成中起作用
Heidi Tran1, Atomu Sawatari1, Catherine A Leamey1
1School of Medical Science, FMH, University of Sydney, Sydney, New South Wales, Australia.
Developmental neurobiology
|September 13, 2023
概括
在小鼠中,10-m3对于提炼thalamostriatal通路连接至关重要. 这项研究详细介绍了它在引导体轴突在条形体内的向中发挥的发展作用.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 分子生物学分子生物学
背景情况:
- 乳头前的途径对许多大脑功能至关重要,但在小鼠中,它的发育形成仍然不太清楚.
- 众所周知,Ten-m3是Ten-m/teneurin/Odz家族的成员,它会影响成熟的乳头状体外投射,但它的发育作用尚不清楚.
研究的目的:
- 为了阐明来自小鼠的副核 (PFN) 的thalamostriatal投影的正常发育时间线.
- 调查10-m3在这些投影的形成和完善过程中的特定作用.
主要方法:
- 从胚胎第17天 (E17) 到产后第10天 (P10) 的野生类型小鼠中详细观察thalamostriatal投影的发展.
- 在发育过程中对PFN和条纹体中Ten-m3表达模式的分析.
- 使用Ten-m3淘汰赛小鼠进行比较研究,以评估发育异常.
主要成果:
- 十米3在PFN和条形体中表达为E17,具有明显的表达梯度.
- 在野生型小鼠中,PFN轴突从E17开始激活条纹体,通过P7-P10观察到细化和聚类,包括避免条纹体.
- 十立方米的淘汰赛小鼠表现出保存的早期发育,但在P10时显示出地形精度和终端聚类的损失.
结论:
- 十米3在状体矩阵内巩固和精确准thalamic轴突中发挥着重要作用.
- 这些发现澄清了Ten-m3对thalamostriatal通道复杂布线的发展贡献.
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