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在ADHD中分析血清VEGF,IGF-1和HIF-1α水平

Emre Ertürk¹, Ümit Işık², Fevziye Burcu Şirin¹

¹Süleyman Demirel University, Isparta, Turkey.

Journal of attention disorders

|September 13, 2023

概括

这项研究研究了患有ADHD的儿童的血管内皮生长因子 (VEGF),胰岛素样生长因子1 (IGF-1) 和缺氧诱导因子1-alpha (HIF-1α). 在ADHD和健康儿童之间没有发现生长因子水平的显著差异.

科学领域:

神经科学是一个神经科学.
儿科儿科儿科
遗传学是一个遗传学.

背景情况:

神经生成对大脑发育至关重要.
像VEGF,IGF-1和HIF-1α这样的生长因子在神经发生过程中起作用.
这些因素的失调可能会导致注意力缺陷/多动障碍 (ADHD).

研究的目的:

调查VEGF,IGF-1和HIF-1α在ADHD病原发生过程中的潜在作用.
为了比较患有ADHD和没有ADHD的儿童中这些生长因子的血清水平.

主要方法:

一项涉及40名被诊断患有多动症和多动症的儿童和40名健康儿童的病例控制研究.
参与者的年龄从7岁到13岁不等.
测量了VEGF,IGF-1和HIF-1α的血清水平,并在两组之间进行了比较.

主要成果:

在患有ADHD的儿童和健康对照者之间没有观察到血清VEGF,IGF-1或HIF-1α水平的显著差异.
在血清VEGF水平和家长评级的ADHD症状 (T-DSM-IV-S AD子表) 之间发现了负相关性.
在血清IGF-1水平和家长评级的ADHD症状 (T-DSM-IV-S AD子表) 和情绪症状 (SDQ ES子表) 之间发现了积极的相关性.

结论:

该研究没有发现ADHD儿童的VEGF,IGF-1和HIF-1α水平有显著差异.
相关发现表明这些生长因素与ADHD症状严重程度之间存在潜在的,尽管复杂的关联.
需要对更大的样本进行进一步的研究,以澄清这些生长因子在ADHD中的作用.

关键词:

更多关于 ADHD ADHD 的文章这就是HIF-1α.在IGF-1的基础上,IGF-1 在VEGF中,VEGF是VEGF.增长因素增长因素增长因素

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