在一个无极,非神经元动物的热毒性
Grace Zhong1, Laurel Kroo2, Manu Prakash1,3
1Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Journal of the Royal Society, Interface
|September 13, 2023
概括
没有大脑的Trichoplax adhaerens表现出强大的热触力,感知热梯度. 纳灵宁是一种TRPM3对手,抑制了这种行为,为早期神经系统进化提供了洞察力.
科学领域:
- * 动物行为与进化
- *神经科学和感官生物学
- * * 海洋生物学 海洋生物学
背景情况:
- *神经回路是动物决策的关键.
- *研究无脑动物为神经系统的进化提供了洞察力.
- * Trichoplax adhaerens (Placozoa) 是早期分离的无极动物,缺乏神经元和肌肉.
研究的目的:
- * 为了研究没有神经元的动物Trichoplax adhaerens的热毒性行为.
- * 为研究无极生物的决策制定定量试验.
- * 探索早期元生动物中热暗示检测的基础分子机制.
主要方法:
- * 开发了一个长期成像设置,以观察T. adhaerens在热梯度中.
- * 量化行为反应,包括速度和方向,在不同的温度.
- *使用了TRPM3抗剂naringenin来探测TRP通道的作用.
主要成果:
- *T. adhaerens在低至0.1°C cm-1.1的梯度中表现出强大的正热阻力.
- *热发生在几个小时内,独立于昼夜节律,在17°C至22.5°C的温度范围内.
- * 纳灵宁显著抑制热毒性,表明TRPM3参与;行为是独立于大小的.
结论:
- *三角附体表现出复杂的热导航,尽管缺乏神经元和定义的身体轴.
- * 这一发现为研究感官处理和决策的演变提供了一个模型.
- *这些发现对于了解海洋动物对海洋变暖的反应以及神经系统的起源至关重要.
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