在N-ERD患者的肺功能和喘临床控制,在现实世界的证据背景下进行三年随访
Gandhi Fernando Pavón-Romero1, Ramcés Falfán-Valencia2, Katia Vanessa Gutiérrez-Quiroz1
1Department of Immunogenetics and Allergy, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.
Journal of asthma and allergy
|September 13, 2023
概括
与喘组 (AG) 相比,带有息肉的鼻鼻炎 (N-ERD) 患者表现出更好的基线肺功能和喘控制. 然而,N-ERD患者需要更多的白三烯受体抗剂 (LTRA) 来持续治疗喘.
科学领域:
- 肺部病理学 肺部病理学
- 过敏和免疫学 过敏和免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 带有息肉的鼻鼻炎 (N-ERD) 是一种独特的喘表型.
- 了解N-ERD的长期管理和结果对于优化患者护理至关重要.
研究的目的:
- 评估N-ERD患者的肺功能和临床喘控制在三年内.
- 根据GINA指南,比较N-ERD和一般性喘患者 (AG) 之间的结果.
主要方法:
- 这是一项为期三年的前性研究,涉及75名N-ERD患者和68名AG患者.
- 临床控制,肺功能 (LF) 和药物使用 (吸入性皮质类固醇 (ICS),口服皮质类固醇 (OCS),白血素受体对抗剂 (LTRA)) 的评估基于GINA-2014指南.
- 基线和治疗开始后的一年,两年和三年的变量比较.
主要成果:
- 与AG相比,N-ERD患者表现出卓越的基线肺功能和更好的临床喘控制.
- AG患者最初需要比N-ERD患者更高剂量的ICS和更多的短期OCS使用.
- N-ERD患者始终需要更多的LTRA,其中三分之一需要双重治疗 (例如,ICS + LTRA) 来控制.
- 随着时间的推移,肺功能在AG中得到改善,而在N-ERD中保持稳定.
- 从第二年开始,临床喘控制在两组之间变得可比.
结论:
- 按照GINA的指导方针,大约三分之一的N-ERD患者通过高剂量的ICS获得足够的肺功能和喘控制.
- 很少有N-ERD患者需要继续使用第二种药物,如LTRA,以有效控制喘.
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