评估东南亚的血小板缺血和慢性肝病:一个多中心的截面研究
Ramsha Sohail1, Imran H Hassan2, Mah Rukh3
1Department of Medicine, Jackson Park Hospital, Chicago, USA.
Cureus
|September 13, 2023
概括
在东南亚的慢性肝病 (CLD) 患者中,血小板缺血 (TCP) 和白血病相关. 像纤维化指数 (FI) 和MELD- (Na) 这样的非侵入性得分有助于评估CLD的严重程度和预后.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 血液学 血液学 血液学
- 流行病学 流行病学
背景情况:
- 慢性肝病 (CLD) 是东南亚的一个重大健康问题.
- 血小板缺血 (TCP) 是一个常见的并发症在CLD患者.
- 了解CLD进展的原因和预测因素对于患者管理至关重要.
研究的目的:
- 确定东南亚三级保健中心中CLD患者中TCP的流行率.
- 调查该地区CLD的各种病因.
- 评估纤维化指数 (FI) 和末期肝病- (MELD-Na) 评分模型在评分CLD严重程度和预测结果中的实用性.
主要方法:
- 这是一项多中心,横截面的研究,涉及来自东南亚15家三级医院的377名CLD患者.
- 收集的数据包括人口统计数据,烟草使用,潜在的CLD病因,贫血,白血病,全细胞衰竭,感染状况和肝硬化.
- 评估肝功能衰竭指标,TCP,肝移植 (LT) 清单,并计算MELD-Na和FI分数.
主要成果:
- 在64%的CLD患者中观察到血小板缺血 (TCP),在白血病患者中风险明显更高 (89.5%与52.5%,p=0.003).
- 最常见的CLD原因是无法诊断的 (31%),自身免疫性 (26%),C型肝炎病毒 (21%),B型肝炎病毒 (14%),以及阴囊 (8%).
- 大多数患者 (98%) 患有不补偿性肝病. MELD分数和FI值分别为16.89 ± 6.42和4.1 ± 1.06. 这两个值分别为16.89 ± 6.42和4.1 ± 1.06. 肝硬化患者 (83.1%) 与非肝硬化患者 (59.6%,p=0.001) 的需要较高.
结论:
- 白血病和TCP可能相互关联,影响东南亚人群中的CLD治疗和预后.
- 非侵入性标志物如FI和MELD-Na得分有效评估肝纤维化和疾病严重程度,改善患者管理.
- 在东南亚,需要提升对CLD的早期诊断,提高临床医生的对非传染性CLD原因的认识.
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