为鼻内注射而设计的载有胰岛素的粘粘性纳米颗粒的合成:专注于新的扩散介质
Tahereh Jamshidnejad-Tosaramandani1,2,3, Soheila Kashanian1,4, Isaac Karimi2
1Nanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University, Kermanshah, Iran.
Frontiers in pharmacology
|September 13, 2023
概括
载有胰岛素的基托桑纳米颗粒提供了一个有前途的非侵入性鼻内药物递送方法. 一种新的克雷布斯-亨赛莱特缓冲溶液有效地保持了 ex vivo 扩散研究的鼻腔组织活力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
背景情况:
- 鼻内注射可以使药物在中枢神经系统中进行非侵入性输送.
- 粘粘性聚合物,如奇托桑,可以提高鼻内药物输送系统的停留时间.
- 开发有效的ex vivo模型对于评估鼻内药物递送性能至关重要.
研究的目的:
- 为了合成和表征胰岛素装载的奇托桑纳米颗粒用于鼻内注射.
- 评估这些纳米颗粒在鼻子组织上的粘粘性和安全性.
- 研究一种使用Krebs-Henseleit缓冲器评估鼻内药物输送的新型ex vivo扩散方法.
主要方法:
- 合成含有胰岛素的奇托桑纳米颗粒.
- 物理化学特征包括尺寸,多分散性指数和泽塔潜力.
- 使用Krebs-Henseleit缓冲器和模拟鼻液的弗朗茨扩散细胞进行了ex vivo扩散研究.
- 鼻腔组织的组织病理学分析.
主要成果:
- 球形纳米粒子 (165.3 nm直径,PDI 0.24,泽塔电位+21.6 mV) 显示出粘膜粘合.
- 在鼻腔组织中没有观察到明显的毒性.
- 克雷布斯-亨塞莱特缓冲器保持了组织活力,并作为一个合适的扩散介质,与模拟的鼻液相比.
结论:
- 含有胰岛素的基托桑纳米颗粒因其粘粘性和无毒性而适合鼻腔输送.
- 克雷布斯-亨塞莱特缓冲溶液是模拟鼻液的可行替代品,用于鼻药物输送系统的ex vivo评估.
- 这项研究提出了一种新且有效的ex vivo方法,用于评估鼻内药物输送性能.
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