通过转录学和网络药理学方法探索COPD相关骨质疏松症治疗修饰的Bu-Shen-Yi-Qi的机制
Yuanyuan Zhong1,2, Bin Wang1,2, Wenjing Chen1,2
1Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Drug design, development and therapy
|September 13, 2023
概括
修改后的Bu-Shen-Yi-Qi (MBSYQ) 有效地治疗与慢性阻塞性肺病 (COPD) 相关的骨质疏松症. 它通过改善氧代谢和激活关键信号通路来起作用,提供了一种新的治疗方法.
科学领域:
- 综合医学是一个整体的医学.
- 药理学 药理学是指药理学的学科.
- 肺部病理学 肺部病理学
背景情况:
- 骨质疏松症是慢性阻塞性肺病 (COPD) 患者的重要并发症.
- 关联COPD和骨质疏松症的潜在机制是复杂的,并未完全理解.
- 目前对COPD相关的骨质疏松症的治疗方法有限.
研究的目的:
- 为了研究修改的Bu-Shen-Yi-Qi (MBSYQ) 对与COPD相关的骨质疏松症的治疗疗效.
- 阐明MBSYQ在这种条件下的作用背后的分子机制.
主要方法:
- 在MBSYQ的活性化合物,点和途径的预测.
- 通过长期暴露在香烟烟雾中,建立了COPD诱导的骨质疏松症的老鼠模型.
- 评估肺部组织病理学,骨微观结构和基因表达 (RNA测序,RT-PCR,西部斑).
- 分子对接以验证药物标相互作用.
主要成果:
- MBSYQ确定了228个治疗点,主要调节MAPK和PI3K/AKT信号通路.
- 在体内,MBSYQ减轻了肺病理,并逆转了COPD骨质疏松症大鼠的骨损失和微观结构损伤.
- MBSYQ上调了与抗氧化应激和有氧呼吸相关的基因,GSEA证实了MAPK和PI3K/AKT通路调节.
结论:
- MBSYQ在预防和治疗COPD相关的骨质疏松症方面表现出有效性.
- 治疗效益部分由改善的氧化代谢和MAPK和PI3K/AKT通路的激活介导.
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