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Updated: Jul 16, 2025

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

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推断蛋白质变体对蛋白质与蛋白质相互作用的影响,使用可解释的变压器表示

Zhe Liu1, Wei Qian1, Wenxiang Cai1

  • 1Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Research (Washington, D.C.)
|September 13, 2023
PubMed
概括

我们开发了MIPPI,这是一种深度学习模型,可以预测遗传变异如何影响蛋白质相互作用. 这种工具有助于识别引起疾病的突变,并了解它们的功能影响.

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Identification of Protein Interacting Partners Using Tandem Affinity Purification

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Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...
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