腰部V3内部神经元提供直接刺激性突触输入到胸部交感前神经元,连接运动和自主脊柱系统
Camila Chacon1, Chioma V Nwachukwu1, Narjes Shahsavani1
1Spinal Cord Research Centre, Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Frontiers in neural circuits
|September 13, 2023
概括
脊髓研究揭示了腰部运动网络和胸部交感前神经元 (SPN) 之间的直接联系. 这一发现揭示了一个新的脊髓内路径,协调运动和自主功能.
科学领域:
- 神经科学是一个神经科学.
- 自主神经系统的自主神经系统
- 发动机控制器的控制器
背景情况:
- 交感自主系统与运动一起激活,但神经协调机制尚不清楚.
- 胸脊髓中的交感前神经元 (SPN) 支持运动需求.
- 脊柱运动器官和交感系统可以独立于大脑输入而激活.
研究的目的:
- 调查协调运动和交感激活的潜在脊髓内机制.
- 为了测试腰椎脊髓神经元与胸部SPN发生突触的假设.
主要方法:
- 在腰部段内注入前级标志物,以识别SPNs的输入.
- 在SPN中记录了全细胞补丁的记录.
- 对V3内神经元 (INs) 及其终端的光遗传激活.
主要成果:
- 来自腰部V3 INs的突触接触在所有胸膜中都存在.
- 在SPN中,8-20%的谷氨酸输入来自腰部V3 INs.
- 对V3 INs的光遗传激活诱导了SPNs中的长期脱极化和动作潜力.
结论:
- 证明腰部运动和胸部交感网络之间的直接脊髓内连接.
- 表明脊髓在协调运动和自主系统方面具有一般功能.
- 确定V3内部神经元是这种脊髓内传播的关键介质.
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