补充剂对改善不育糖尿病男性精子参数的影响
Hakimeh Akbari1, Leila Elyasi2, Ali Asghar Khaleghi1
1Cellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash, Iran.
Journal of obstetrics and gynaecology of India
|September 13, 2023
概括
补充剂通过减少DNA损伤和增强运动性来改善糖尿病男性的精子质量. 这表明.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 营养生物化学 营养生物化学
- 安德罗学与人类学
背景情况:
- 糖尿病 (DM) 对男性生殖系统产生不利影响.
- (Zn) 具有抗氧化和抗亡性质,对于清除活性氧物种 (ROS) 至关重要.
- 精子染色素和DNA完整性对于男性生育能力至关重要.
研究的目的:
- 研究补充剂对精子染色质的保护作用.
- 在患有糖尿病的男性中评估精子脱氧核糖核酸 (DNA) 完整性.
主要方法:
- 一项涉及43名不育的伊朗男性 (糖尿病和非糖尿病组) 的干预研究.
- 随机分组接受了正常盐水或硫酸 (25毫克/天64天).
- 评估了精子分析 (数量,形态,运动性),水平,蛋白胺缺乏 (CMA3) 和DNA碎片化 (SCD).
主要成果:
- 补充剂显著减少了糖尿病男性的精子形态异常 (子,头部,尾部).
- 在施用后观察到精子运动的改善 (A,B,C类型).
- 减少了异常的精子形态和DNA碎片化,由SCD得分的变化表明.
结论:
- 补充剂有效地抵消糖尿病引起的对精子参数,染色素和DNA完整性的负面影响.
- 可以被认为是糖尿病不育男性有益的食补充剂.
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