编程细胞死亡联体1表达在突节自然杀手/T细胞淋巴瘤中的预测意义及其与临床病理特征的相关性:系统性审查和元分析
Wen Li1, Qiaoling Zheng1, Xiaofeng Luo2
1Department of Pathology, Fujian Medical University Union Hospital, Fuzhou, China.
Translational cancer research
|September 13, 2023
概括
在外自然杀手/T细胞淋巴瘤 (ENKTL) 中,编程细胞死亡配体1 (PD-L1) 表达没有显著影响整体存活率. 然而,PD-L1阳性与有利的临床特征相关,表明潜在的治疗益处预测.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 编程细胞死亡配体1 (PD-L1) 表达越来越多地被识别为血液性恶性瘤.
- 在外自然杀手/T细胞淋巴瘤 (ENKTL) 中PD-L1的预后价值仍然在很大程度上未被探索.
- 这一元分析研究了ENKTL中PD-L1的预测意义.
研究的目的:
- 为了确定瘤PD-L1表达在外自然杀手/T细胞淋巴瘤 (ENKTL) 的预后值.
- 在ENKTL患者中探索PD-L1表达和生存结果之间的关联.
- 为了确定PD-L1表达和临床病理特征之间的潜在相关性.
主要方法:
- 在PubMed,Embase,Web of Science和CNKI数据库中进行了系统的文献搜索.
- 包括了符合条件的观察性研究,报告了ENKTL患者的PD-L1表达和生存结果.
- 使用Review Manager 5.3和STATA 17.0进行了元分析,计算了聚合危险比率 (HRs) 和赔率比率 (ORs).
主要成果:
- 分析了7项涉及433名ENKTL患者的研究.
- 在瘤PD-L1表达和整体存活 (OS) (HR = 1.35,P=0.559) 之间没有发现显著的关联.
- PD-L1阳性表达与国际预后指数 (IPI) 较低的得分 (OR = 2.46,P=0.03),良好的表现状态 (OR = 1.97,P=0.02) 和良好的治疗反应 (OR = 2.61,P=0.05) 显著相关.
结论:
- 在ENKTL患者中PD-L1阳性表达与有利的临床特征相关.
- 在ENKTL中,PD-L1表达可以作为治疗效益的潜在预测指标.
- 需要进一步的大规模,高质量的研究来验证这些发现.
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