威尔逊病患者的乙型肝炎病毒感染:一项大型回顾性研究
Hua-Ying Zhou1, Xu Yang1, Kai-Zhong Luo1
1Department of Infectious Diseases, Institute of Hepatology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
World journal of gastroenterology
|September 13, 2023
概括
乙型肝炎病毒 (HBV) 感染在2.1%的威尔逊病 (WD) 患者中存在,往往会延迟WD诊断. 乙型肝炎病毒感染显著增加了WD患者严重肝病和死亡率的风险.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 遗传代谢障碍 遗传代谢障碍 遗传代谢障碍
- 传染性疾病 传染性疾病
背景情况:
- 威尔逊病 (WD) 是一种普遍存在的遗传代谢性肝脏疾病.
- 伴随性疾病可以显著影响WD患者的结果.
- 有限的数据存在于乙型肝炎病毒 (HBV) 感染的流行率和WD患者的影响.
研究的目的:
- 确定威尔逊病患者中HBV感染的流行率.
- 评估同时感染HBV对WD进展和结果的临床影响.
主要方法:
- 对915名威尔逊病患者的临床数据进行了回顾性分析.
- 与同时患有WD和HBV感染的患者之间的结局的比较与孤立的WD.
主要成果:
- 当前和过去的HBV感染的患病率分别为2.1%和9.2%.
- 同时的WD和慢性乙型肝炎 (CHB) 感染 (19名患者) 导致WD诊断延迟 (32.5个月与10.5个月).
- 同时患有WD和CHB的患者的严重肝病率 (63.1%与19.3%) 和死亡率 (36.8%与4.1%) 显着更高.
结论:
- 目前的HBV感染影响了WD患者的2.1%,经常导致错过WD诊断.
- 乙型肝炎病毒感染是WD中严重肝病的独立风险因素.
- 在患有CHB感染的患者中,考虑WD诊断至关重要.
相关概念视频
01:26Diseases of the Liver and Gallbladder
621
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
621
01:29Pulmonary Tuberculosis I
262
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
262