峰值步骤:在肺动脉高血压中增加已批准的治疗后,活动能力得到改善
Daniel Lachant1, Allison Light1, Michael Lachant1
1Department of Medicine, Division of Pulmonary and Critical Care Medicine University of Rochester Medical Center Rochester New York USA.
新型的动图测量,特别是高峰分钟步骤,可以在治疗强化后检测肺动脉高血压 (PAH) 患者的活性增加. 标准活动指标没有显示显著变化.
科学领域:
- 心脏病学和肺部医学.
- 生物医学工程和可穿戴技术
背景情况:
- 肺动脉高血压 (PAH) 与身体活动减少有关,影响临床状态和治疗反应.
- 标准活动指标可能无法充分捕捉PAH患者经历治疗变化的微妙改善.
研究的目的:
- 评估是否标准或新型的动图测量可以在增加治疗后检测到1组PAH患者增加的身体活动.
- 用前性,单中心观测研究和单独的验证队列来验证发现.
主要方法:
- 两组前性观察性研究:治疗强化 (TI) 和稳定PAH患者.
- 使用手腕 (ActiGraph) 和胸部 (MC10) 加速度计对7天的基线和随访期进行活动监测.
- 对活动时间,每日步骤和像峰值分钟步骤这样的新型指标的专有算法的分析.
主要成果:
- 在TI组中,在基线和随访之间没有观察到平均每日步骤或活动时间/强度的显著变化.
- 在治疗补充后,在TI组中检测到顶部5分钟的峰值步骤 (活动能力的衡量标准) 的显著增加.
- 稳定组在活动指标上没有显著变化,证实了研究结果对治疗反应的特异性.
结论:
- 峰值分钟步骤是一种新型的动图学度量,作为一个敏感的,对PAH体育活动变化的治疗反应的标记.
- 由于混杂因素,标准活动指标在检测治疗相关改善方面可能不那么有效.
- 动图学,特别是新型指标,对监测治疗疗效和指导PAH临床管理具有前景.
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