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Updated: Oct 2, 2026

In vivo Evaluation of Mucociliary Clearance in Mice
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In vivo Evaluation of Mucociliary Clearance in Mice

Published on: December 18, 2020

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定量Tc-阿尔伯明合物鼻腔粘膜清除作为原发性状动症的结果

June K Marthin1, Kim G Nielsen1,2,3, Jann Mortensen2,4,5,3

  • 1Danish PCD Centre, Paediatric Pulmonary Service, ERN Accredited, Department of Paediatric and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

ERJ open research
|September 13, 2023
PubMed
概括

鼻膜清除 (NMC) 速度是初级膜动症 (PCD) 的可靠指标. 这项研究发现PCD患者中没有NMC,使他们与健康对照区分开来.

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Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
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