在瑞士肺炎Laus队列中,小呼吸道功能障碍的流行率
Brice Touilloux1,2, Cedric Bongard1, Benoit Lechartier1
1Division of Pulmonology, Department of Medicine, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
ERJ open research
|September 13, 2023
概括
小型呼吸道功能障碍 (SAD) 的患病率在空气污染较低的欧洲地区很低. 在这个人群中,吸烟,而不是颗粒物 (PM2.5) 是SAD的主要危险因素.
科学领域:
- 肺部医学 肺部医学
- 环境健康 环境健康
- 流行病学 流行病学
背景情况:
- 颗粒物 (PM2.5) 暴露与小呼吸道功能障碍 (SAD) 有关.
- 评估欧洲低空气污染地区的SAD患病率至关重要.
- 这项研究研究了瑞士队列中低环境PM2.5水平的SAD.
研究的目的:
- 为了确定小呼吸道功能障碍 (SAD) 的患病率.
- 为了确定与低空气污染环境中SAD相关的风险因素.
- 评估不同螺旋测量标准对SAD患病率估计的影响.
主要方法:
- 根据最大中呼吸流量 (MMEF) 标准 (<65%预测值或<正常的下限) 使用螺旋测量来定义SAD.
- 两变量和多变量分析检查了与年龄,性别,BMI,呼吸系统症状和吸烟状况的关联.
- 从国家数据库中获得了研究期间 (2010-2020) 的PM2.5平均水平.
主要成果:
- 在3351名参与者中,SAD患病率为12.7% (MMEF <65%PV) 和5.0% (MMEF
- 抑郁症与年龄,吸烟状况,咳,吐和呼吸障碍显著相关.
- 在这种低PM2.5 (<15μg·m−3) 的环境中,经常吸烟者至少占SAD病例的72%.
结论:
- 低PM2.5暴露可能有助于观察到的低SAD流行率.
- 在空气污染最小的地区,吸烟被确定为SAD的主要风险因素.
- 使用MMEF<65%PV可能会导致老年人过度诊断SAD.
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