根据Duffy的基因型和表型,Plasmodium vivax的演变和感染的耐药性模式
Yelson Alejandro Picón-Jaimes1, Ivan David Lozada-Martinez2, María Camila Forero Buelvas3
1Fac Ciències Salut Blanquerna, Univ Ramon Llul, Barcelona, Spain.
Le infezioni in medicina
|September 13, 2023
概括
达菲阴性基因型,曾经被认为是预防疟疾的保护性,现在显示增加易感性Plasmodium vivax感染. 这种转变需要重新评估疟疾耐药性模式和公共卫生战略.
科学领域:
- * 分子生物学和遗传学
- * 传染病和寄生虫学
- * 进化医学和公共卫生
背景情况:
- * 达菲蛋白是一种细胞表面受体,对化学激素信号传递和红细胞被虫寄生虫入侵至关重要.
- * 达菲抗原受体基因 (DARC) 多态性影响达菲蛋白表达,并且在地理位置上有所不同.
- * 从历史上看,达菲阴性与保护抗生素活疟疾有关.
研究的目的:
- *分析Plasmodium vivax感染和耐药性模式的进化变化.
- * 调查杜菲基因型和表型在当代疟疾耐药性中的作用.
主要方法:
- *对Duffy基因型/表型分布和Plasmodium vivax流行情况的现有文献的综述.
- *对达菲多态和疟疾感染率的地理差异分析.
- *当前阻力模式与历史数据的比较.
主要成果:
- * 达菲基因型,表型和Plasmodium vivax连接体/受体多态的地理分布高度可变.
- *最近的数据显示,在Duffy阴性个体中,Plasmodium vivax的流行率显著增加.
- *在一些人群中,达菲阴性与百分之百的vivax疟疾患病率有关.
结论:
- * 杜菲阴性抗生素对活性疟疾的保护作用已经减弱或逆转.
- * 显而易见的是,疟疾耐药性模式发生了显著的进化变化.
- *迫切需要公共卫生研究和干预策略,以应对Duffy阴性人群中活体疟疾的流行率上升.
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