更新Mpox:一个简短的叙事审查
Spinello Antinori1,2, Giacomo Casalini1,2, Andrea Giacomelli2
1Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, Italy.
Le infezioni in medicina
|September 13, 2023
概括
自2022年5月以来的全球流行病Mopox主要影响与男性发生性关系的男性. 虽然通常是轻微的,但严重的病例发生在免疫受损的个体中,疫苗接种提供了有效的预防.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 马波克斯 (原名麻疹) 在2022年5月从被忽视的热带疾病转变为全球流行病.
- 疫情主要影响与男性发生性关系的男性,传播途径各异,包括职业和垂直暴露.
- 很大一部分病例涉及同时感染人类免疫缺陷病毒 (HIV) 或使用人类免疫缺陷病毒暴露前预防 (PrEP).
研究的目的:
- 总结2022年全球Mpox疫情的流行病学,临床表现和管理.
- 为了突出与特有Mpox病例相比,临床表现的差异.
- 审查目前对Mpox的治疗和预防策略.
主要方法:
- 发表的Mpox案件的系统审查和元分析.
- 从全球爆发的流行病学数据的分析.
- 对临床特征和结果的审查.
主要成果:
- 截至2023年5月,全球Mpox病例超过87000例,其独特的临床特征包括较少的病变,前生殖器局部化和异步进展.
- 无症状感染在1.8-6.5%的风险人群中被发现.
- 住院率约为6%,病例死亡率低于0.1%,尽管在艾滋病毒感染者中观察到严重免疫缺陷的严重结果.
结论:
- 马普克斯需要持续的监测和有针对性的公共卫生干预措施,特别是在风险人群中.
- 推Tecovirimat用于严重病例,尽管随机对照试验证据有限.
- 接种JYNNEOS疫苗有效地减少了Mpox的发生率.
关键词:
蒙波克斯 (Mox Mpox) 是一个新兴传染病是新出现的传染病.性传播感染性传播感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性感染性皮肤病变 皮肤病变德科维里马特 (tecovirimat) 是一个更多相关视频
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