美国男性勃起功能障碍和良性前列腺增生相关下尿道症状的医疗保健资源利用和治疗模式:一项回顾性数据库研究
Irwin Goldstein1, Tarek Hassan2, Kelly Zou3
1Department of Sexual Medicine, Alvarado Hospital, San Diego, CA, USA.
Patient preference and adherence
|September 13, 2023
概括
与非化酶-5抑制剂 (PDE5i) 相比,在患有勃起功能障碍 (ED) 和良性前列腺激增 - 下泌尿道症状 (BPH-LUTS) 的患者中使用塔达拉菲尔与医疗保健资源利用率 (HCRU) 显著降低有关. 服用塔达拉菲尔的患者也表现出更好的坚持和持续性,特别是在每天服用一次剂量时.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药物经济学 药物经济学
- 现实世界的证据.
背景情况:
- 勃起功能障碍 (ED) 和良性前列腺激增相关的下泌尿道症状 (BPH-LUTS) 是影响生活质量的常见疾病.
- 治疗方案包括固酶-5抑制剂 (PDE5i) 和其他疗法,对医疗保健资源利用 (HCRU) 有不同的影响.
研究的目的:
- 为了比较tadalafil和非PDE5i治疗对ED和BPH-LUTS的男性的HCRU结果.
- 根据美国的剂量方案来评估tadalafil的坚持和持久性.
主要方法:
- 这是一项非干预性,现实世界的证据研究,使用IQVIA美国PharMetrics Plus索赔数据库.
- 包括45岁或以上的男性,患有ED和BPH-LUTS,接受过tadalafil或非PDE5i治疗.
- 在12个月内对所有原因和疾病特定的HCRU进行分析,并根据剂量评估tadalafil的坚持和持久性 (根据需要而不是每天一次).
主要成果:
- 该研究包括11,351名塔达拉菲尔使用者和48,722名非PDE5i使用者.
- 塔达拉菲尔使用者表现出明显较低的全因和疾病特异性HCRU,包括更少的医生访问,急诊室访问和住院治疗.
- 与按需要 (a.n.) 相比,每日一次 (OD) 剂量的塔达拉菲尔观察到更高的持久性和坚持率. 剂量. 剂量. 这是.
结论:
- 与非PDE5i疗法相比,tadalafil治疗与ED和BPH-LUTS患者的医疗资源利用率降低有关.
- 塔达拉菲尔表现出良好的坚持性和持久性,特别是在每天服用一次时,支持其在管理这些疾病中的临床实用性.
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